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PLX076439
GSE101788: Global transcriptional changes associated with AI-10-49 in inv(16) leukemic cells [RNA-seq]
- Organsim human
- Type RNASEQ
- Target gene
- Project ARCHS4
We recently reported the discovery of a small molecule inhibitor, AI-10-49 which can specially inhibit the protein-protein interaction between RUNX1 tumor suppressor and CBF-SMMHC oncogene. We also demonstrated that AI-10-49 can re-establish the RUNX1 transcriptional program in inv(16) cells and can extend the survival of inv(16) leukemic mice. To identify the transcriptional changes associated with AI-10-49, we performed RNA-seq analysis in ME-1 cells [human inv(16) leukemia cell line] treated with AI-10-49. SOURCE: Lucio Castilla (lucio.castilla@umassmed.edu) - University of Massachusetts
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