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Learn MoreTo further identify potential mechanisms involved in combining RG7388 with temozolomide, GSEA was performed and revealed that RG7388 and temozolomide act cooperatively to upregulate the p53 pathway and downregulate MYC targets, the former resulting in significantly greater induction of several apoptotic genes. SOURCE: John Casement (john.casement@newcastle.ac.uk) - Newcastle University
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