PLX291591

GSE106246: An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

mRNA quality control mechanisms ensure fidelity of protein translation. An evolutionarily conserved component of the quality control machinery, Dom34/Pelota (Pelo), rescues stalled ribosomes. Here we show that Pelo is required for mammalian epidermal homeostasis. Our study reveals a novel role for the ribosome-rescue machinery in mammalian tissue homeostasis and an unanticipated specificity in its impact on different stem cell populations. SOURCE: Fiona,M,Watt (fiona.watt@kcl.ac.uk) - King's College London

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