PLX192839

GSE112382: Polycomb repressive complex 1 (PRC1) role in skin epithelium development [Epi Ring1a/b dKO]

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Polycomb repressive complexes (PRC) 1 and 2 are essential chromatin regulators of cell identity. PRC1, a dominant executer of Polycomb-mediated control, functions as multiple sub-complexes that possess catalytic-dependent H2AK119 mono-ubiquitination (H2AK119ub) and catalytic-independent activities. Here, we show that despite its well-established repressor functions, PRC1 binds to both silent and active genes. Through in vivo loss-of-function studies, we show that global PRC1 function is essential for skin development and stem cell (SC) specification. SOURCE: Dejian Zhao (dejian.zhao@einstein.yu.edu) - Albert Einstein College of Medicine

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