PLX228234

GSE115187: Gene expression changes in Ing1- and Gadd45a- single- or double-knockout mouse embryonic fibroblasts

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

ING1b and GADD45a are nuclear proteins involved in the regulation of cell growth, apoptosis and DNA repair. We previously found that ING1b is required to target GADD45a-mediated active DNA-demethylation via TET1 to specific loci. In order to study the impact of ING1-GADD45a on gene expression, we compared the expression profile of wildtype mouse embryonic fibroblasts (MEFs) with Ing1- and Gadd45a- single- or double-knockout (DKO) MEFs. SOURCE: Emil Karaulanov (e.karaulanov@imb-mainz.de) - Institute of Molecular Biology

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