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Learn MoreHematopoietic stem cell (HSC) gives rise to all the hematopoietic cells. The stemness of HSC is strictly controlled by some transcription factors. Here we show that both of Nras mutation (NrasG12D) and Nup98-Hoxa10HD (NA) improve the transplantation competition ability of HSC. Pathways and differential expression genes analysis show that NrasG12D and NA proteins enhance the competitiveness of HSCs via distinct signaling mechanisms. SOURCE: Wang Jinyong (wang_jinyong@gibh.ac.cn) - Guangzhou Institutes of Biomedicine and Health (GIBH)
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