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PLX042609
GSE122836: Nrf2 activation promotes lung cancer metastasis by blocking degradation of Bach1
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
Purpose: The goal of this study is to analyze the transcriptional pathways regulated by Fbxo22 and Keap1 in mouse lung adeno carcinoma cells.; Methods: mouse lung adeno carcinoma cells either Keap1 wild type (KP) or mutant (KPK), have been transfected for 3 days with siRNA targeting Fbxo22. Knock down efficiency has been evaluated by western blot (using specific antibody for Fbxo22) and qPCR (using specific oligos for Fbxo22) .; Results: The transcriptomic analysis helps us to support our finding that loss of either Keap1 or Fbxo22 induces metastases SOURCE: Shaowen Jiang (sj2641@nyu.edu) - Applied Bioinformatics Lab NYU Langone
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