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PLX167484
GSE123357: Mouse Estrogen Treatment Study Analysis of Peri-prostatic Fat
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
Obesity is associated with an increased incidence of high grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was associated with high grade PC. Possibly, interventions that suppress periprostatic WAT inflammation will improve outcomes for men with PC. Here, we tested the hypothesis that supplemental 17-estradiol (E2) could decrease periprostatic WAT inflammation in obese male mice. SOURCE: Akanksha Verma (akv3001@med.cornell.edu) - Weill Cornell Medical College
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