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PLX062316
GSE123657: mRNASeq of z_Q175 knock-in mouse lines with and without neo cassette
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
In order to determine the effect of neoR gene in Q175 locus, mRNASeq was performed to compare the transcriptional signatures of zQ175 knock-in neo-in (z_Q175 KI) (CHDI-81003003) and zQ175 KI neo-out (Z_Q175 (neo -) KI) (CHDI-81003019) mouse lines. The z_Q175 KI is a knock-in mouse line with humanized exon 1 (190-200 pure CAG repeats) derived from Q140 KI colony. It contains floxed neo cassette upstream of exon 1. The Z_Q175 KI (neo -) KI was generated by crossing the Z-Q175 KI line with a zp3-cre transgenic line to delete out the neo cassette. SOURCE: Jeff Aaronson (jeff.aaronson@chdifoundation.org) - CHDI
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