PLX238964

GSE126332: The transcriptional repressor SNAI2 impairs neuroblastoma differentiation and inhibits response to retinoic acid therapy

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Analyses of the effect of CRISPR/CAS9 mediated knock out of the EMT-transcription factor SNAI2 on the mRNA expression profile of human neuroblastoma SH-SY5Y cells to identify genes that are differentially expressed upon loss of SNAI2. Results provide insight into genes that are repressed by SNAI2 in neuroblastoma cells under normal culture conditions, where loss of SNAI2 enhances the expression of genes involved in biological processes such as neuron development and neuron differentiation. SOURCE: Kirsten Vrenken (k.s.vrenken@prinsesmaximacentrum.nl) - Princess Máxima Center for Pediatric Oncology

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