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Learn MoreCrosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem and cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Ebf1-deficient MSCs have reduced mesenchymal lineage potential. Ebf1 deletion in Cxcl12-abundant reticular (CAR) cells and PDGFR+Sca1+CD45-CD31-Lin- (PS) cells in the bone marrow decreased the numbers of HSPCs and myeloid cells. EBF1 in the bone marrow niche regulates a transcriptional program that determines the functional interactions with HSCs and the long-term balance between the myeloid and lymphoid cell fates. SOURCE: Senthilkumar Ramamoorthy (senthilkumar@ie-freiburg.mpg.de) - Laboratory Rudolf Grosschedl Max Planck Institute of Immunobiology and Epigenetics
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