PLX239355

GSE128870: Transcriptional profiling of the peri-pulmonary vein region of the adult mouse left atrium and corresponding Tbx5-dependence

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

The left atrium consists of three major parts: the peri-pulmonary vein portion, the appendage, and the vestibule. Previous transcriptional profiling of the adult left atrium and identification of the Tbx5-dependent transcriptome has focused on the atrial appendage (Nadadur et al 2016, Science Translational Medicine). In that study, Tbx5 was shown to regulate a gene regulatory network of atrial identity in the appendage and in its absence results in atrial fibrillation. In order to investigate the regional differences in the transcriptome of the left atrium, the left atrial appendage and the peri-pulmonary vein portion from adult mice were compared by RNA-sequencing. Additionally, as Tbx5 is major regulator of atrial identity, the peri-pulmonary vein portion of the atria was likewise examined following removal of Tbx5 using an adult specific conditional knockout of Tbx5. SOURCE: Jeffrey,D.,Steimle (jsteimle@uchicago.edu, jeffrey.steimle@bcm.edu, jsteimle@alumni.nd.edu) - University of Chicago