PLX243342

GSE128911: RNA-seq of breast cancer cell lines post ligand treatment II

• Organsim human
• Type RNASEQ
• Target gene
• Project ARCHS4

Goal: study the impact of estrogen receptor ligands on gene expression in HR+ breast cancer cells; Methods: RNA sequencing; Results: Ligand 4-OH tamoxifen, a selective ER modulator (SERM), promotes transcriptional activation of ER and mimics the transcriptional effect of natural ligand E2 for a subset of ER target genes, consistently across the seven breast cell lines (MDA-MB-134 VI, MDA-MB-330, EFM-19, T-47D, and BT-474). Selective ER degraders (SERD) fulvestrant and GDC-0927 on the other hand do not induce, or induce very weakly the expression of ER target genes. The effect of GDC-0810 depends on the cellular context. SOURCE: Marc Hafner (hafner.marc@gene.com) - Genentech