PLX152903

GSE131344: Xenobiotic-induced perturbations of cis-regulatory elements associated with sensitivity to liver tumor promotion

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Liver cancer susceptibility varies between strains of experimental animal models due to multiple genetic and epigenetic factors. We used DNase I hypersensitivity mapping and transcriptomic profiling to investigate cis-regulatory element and transcriptional perturbations associated with the early stages of phenobarbital (PB)-mediated liver tumor promotion in susceptible versus resistant mouse strains (B6C3F1 versus C57BL/6). SOURCE: Jonathan Moggs (jonathan.moggs@novartis.com) - Novartis

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