PLX129943

GSE137365: Evaluation of the physiological property of D-allulose on obesity and its comorbidities in diet-induced obese mice based on mRNA-seq analysis

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

ackground/Objectives: The aim of the current study was to elucidate the effects of long-term supplementation with D-allulose on obesity and associated comorbidities by analyzing transcriptional and metabolic responses. Subjects/Methods: C57BL/6J mice were divided into three groups and fed a normal diet, high-fat diet (HFD), or high-fat + 5% (w/w) D-allulose diet for 16 weeks. Results: Body weight and body fat mass were significantly decreased in HFD-fed with D-allulose supplemented mice and their levels were similar to that of the normal diet. Also, major symptoms of obesity, such as high plasma lipid profiles and cytokine levels, were attenuated by D-allulose supplementation. D-allulose supplement induced the alteration of mRNA expression in epididymal white adipose tissue (eWAT) and hepatic tissue. D-allulose normalized mRNA expression related lipid metabolism in eWAT and hepatic tissue. In Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway mapper analyses, D-allulose supplementation were down regulated the cytokine-cytokinereceptor interaction, chemokinesignaling pathway, MAPK signaling pathwayandtoll-like receptor signaling pathway in eWAT and hepatic tissue. SOURCE: Youngji Han (youngji.kor.han@gmail.com) - Kyungpook National University