PLX189692

GSE137420: Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-Juvenile Neuronal Ceroid Lipofuscinosis

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We developed an invitro model for Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) using isogenic CLN3 mutated human iPS cell lines and performed transcriptomic profiling of brain organoids derived from these lines to identify transcriptomic changes in the early developing brain model. SOURCE: Jens,Christian,Schwamborn Luxembourg Center for Systems Biomedicine (University of Luxembourg)

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