PLX037618

GSE138153: Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Epigenetic regulation of gene expression through histone modifications like methylation of various lysine residues are essential for embryonic development. Here we removed SETD2, a methyltransferase for histone 3 lysine 36 trimethylation (H3K36me3), in the developing dorsal forebrain in mice and show it is required for proper area patterning (arealization) of the neocortex and the formation of thalamo-cortico-thalamic circuits by maintaining the expression of clustered protocadherin (Pcdh) genes in an H3K36me3 methyltransferase-dependent manner. Moreover, the Setd2 mutant mice exhibit defects in social interaction, motor endurance and spatial memory, reminiscent of patients with the Sotos-like syndrome bearing SETD2 mutations. SOURCE: Lichao Xu (lichao.xu@whu.edu.cn) - Wuhan University