PLX055324

GSE138224: Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

High-throughput RNA-seq analysis was performed using fresh residual CT26 tumors 3 days after incomplete radiofrequency abaltion (iRFA) as well as control tumors. We ound genes encoding damage-associated molecular patterns molecules (DAMPs), proinflammatory cytokines, chemokines, and genes associated with immunosuppression were overexpressed in the iRFA-treated tumor, indicating iRFA elicits inflammation and induces immunosuppression in residual tumors. SOURCE: Liangrong Shi (shiliangrong@csu.edu.cn) - Xiangya Hospital, Central South University

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