PLX067903

GSE140689: Direct induction of retinal ganglion cell-like neurons

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Retinal ganglion cells (RGCs) are the projection neurons in the retina that connect the visual sensing tissue to the brain. We found that Ascl1/Brn3b/Isl1 transcription factor combination can quickly and efficiently reprogramming mouse embryonic fibroblasts (MEFs) into retinal ganglion cell-like neurons (iRGCs). Using RNA-seq, we analyzed the transcriptomes of MEFs infected with Ascl1/Brn3b/Isl1-overexpressing viruses on day 2 or day 7 of reprogramming, or the final iRGCs on day 13 of reprogramming. SOURCE: SHUYI CHEN (chenshy23@mail.sysu.edu.cn) - Zhongshan Ophthalmic Center, SYSU

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