PLX133684

GSE141031: Smooth muscle cell reprogramming in aortic aneurysms [scRNA-Seq]

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

Smooth muscle cell TGF signaling is one of the primary drivers of smooth muscle cell maturation. Inhibition of smooth muscle cell TGF signaling in hyperlipidemic mice induces vessel wall inflammation and vessel wall dilation/dissection and leads aortic aneurysm. We performed scRNAseq method to examine smooth muscle cell gene expression profile using Apoe and SMC specific TGFbR2 KO in Apoe background mice. SOURCE: Michael Simons (michael.simons@yale.edu) - Yale Cardiovascular Research Center Yale University