PLX260049

GSE141725: Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Experimental ocular hypertension (IOP) induces senescence of retinal ganglion cells (RGCs) that mimicks events occurring in human glaucoma. An established transgenic p16-3MR mouse model in which the systemic administration of the small molecule ganciclovir (GCV) selectively kills p16INK4a-expressing cells was used to compare transcriptomes of retinas from IOP and control eyes in GCV-treated and non-treated mice, to investigate how experimental removal of senescent p16INK4a-positive cells impacts retinal cells in conditions resembling glaucoma. SOURCE: Michal Krawczyk (mikrawczyk@gmail.com) - UCSD

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