PLX054842

GSE142417: Interleukin-11 signaling drives vascular smooth muscle phenotypic switching and contributes to aortic remodelling

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

RNA sequencing of primary human aortic or arterial VSMCs after stimulation with transforming growth factor beta-1 (TGF1) revealed marked IL11 upregulation. In vitro, IL11 stimulation of VSMCs resulted in phenotypic switching by increased ECM production and migration/invasion. Neutralizing IL11 antibody treatment abolished phenotypic switching in VSMCs. IL11 plays an important and non-redundant role in VSMC phenotypic switching. SOURCE: Giuseppe D'Agostino (giuseppe.dagostino@duke-nus.edu.sg) - Duke-NUS Medical School

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