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Learn MoreTo provide further insight into the cellular function of the ALS-linked gene C9ORF72, we performed transcriptome sequencing and a genome-wide synthetic lethal CRISPR screen in human U937 myeloid cells lacking C9ORF72. We discovered a strong synthetic lethal genetic interaction between C9ORF72 and FIS1, which encodes a mitochondrial membrane protein involved in mitochondrial fission and mitophagy. SOURCE: Julien CouthouisAaron Gitler Stanford University
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