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PLX003563
GSE143479: Identification of alcohol-induced transcriptional changes in human esophageal epithelial cells via RNA-Seq
- Organsim human
- Type RNASEQ
- Target gene
- Project ARCHS4
The current study is focused on elucidating the effect of acute alcohol challenge on esophageal epithelial cells. We employed in vivo mouse models, ex-vivo 3D-organoids and 2D cell culture to answer this question. RNA-Seq was employed to identify acute alcohol-induced transcriptional changes in human esophageal epithelial cells in-vitro. Acute-alcohol promoted strong mitochondrial damage resulting in bioenergenitic imbalance in esophageal epithelial cells. Autophagy was activated potentially via the AMPK-mTORC1 pathway to promtoe the clearance of damaged mitochondria. SOURCE: Michael Gonzalez (gonzalezm2@email.chop.edu) - The Children's Hospital of Philadelphia
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