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Learn MoreTo explore this question, we will use three different male mouse models including VDR KO mice and transgenic mice with hVDR only expressed in the distal intestine (KO/VDR-Tg). All the mice which are C57BL6J background will be raised until 2-3 months old with standard chow diet (n=3 mice per genotype group). Compared to the KO/VDR-Tg mice without any injection, the same type of mice will be administered 1 ng/g bw 1,25(OH)2D3 at 48, 24 and 6 hours prior to termination to determine both early and late effects of 1,25(OH)2D3. SOURCE: Michael,P,VerziVerzi Rutgers, the State University of New Jersey
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