PLX001797

GSE145469: Co-inhibition of BET proteins and PI3K triggers mitochondrial apoptosis in rhabdomyosarcoma cells

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Remodeling transcription by targeting bromodomain and extraterminal (BET) proteins has emerged as promising anticancer strategy. Here, we identify a novel synergistic interaction of the BET inhibitor JQ1 with the PI3K-specific inhibitor BYL719 to trigger mitochondrial apoptosis and to suppress tumor growth in models of rhabdomyosarcoma (RMS). RNA-Seq revealed that JQ1/BYL719 co-treatment shifts the overall balance of BCL-2 family gene expression towards apoptosis and upregulates expression of BMF, BCL2L11 (BIM) and PMAIP1 (NOXA) while downregulating BCL2L1 (BCL-xL). SOURCE: Christina Grimm (cgrimm6@uni-koeln.de) - University Clinic Cologne

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