Key Features
Enhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.
Learn MorePurpose: The goals of this study are to verify the dynamic changes of hematopoietic endothilium treated by PLB in H1 derived different population of cells during human early hematopoietic differentian.; Methods: mRNA profiles of hESC samples collected from FACS sorted APLNR+ cells treated with PLB during day 2.5 to 5 after hematopoiesis differentiation were generated by deep sequencing using Illumina HiSeq. The sequence reads that passed quality filters were analyzed at the gene and transcript isoform level STAR followed by Cufflinks. The differentially expressed splicing events were analyzed by rMASTs; Conclusions: Our study represents the first detailed analysis the change of hemogenic endothelial progenitors generation treated by PLB , with biologic replicates, generated by RNA-seq technology. By detaied analysis of this data,we found splicing inhibition gave rise to the aberrant splicing of NUMB, which consequently led to the reduced expression of NUMB-S isoform in HEPs SOURCE: Shi Lihong (liyapu@ihcams.ac.cn) - PUMC
View on GEOView in PlutoEnhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.
Learn MoreUse Pluto's intuitive interface to analyze and visualize data for this experiment. Pluto's platform is equipped with an API & SDKs, making it easy to integrate into your internal bioinformatics processes.
Read about post-pipeline analysisView quality control data and experiment metadata for this experiment.
Request imports from GEO or TCGA directly within Pluto Bio.
Chat with our Scientific Insights team