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PLX252048
GSE147666: Identification of genes showing an age related expression in iNKT1, 2, and 17 cells of BALB/c thymus
- Organsim mouse
- Type RNASEQ
- Target gene
- Project ARCHS4
In this study we applied RNA high-throughput seqencing to compare the global gene expression of young adult and aged iNKT subset in thymus of BALB/c mice.; We found that only a small number of genes exerted a profound and statistically significant up- or downregulation upon ageing whereas a plethora of minor changes in the gene expression pattern were evident. However, significant age-related differences in expression of a variety of genes such as Histone genes, Gzma, CD25 and others might; correlate with functional adaptations to the drastically altering thmyus micro-environment during aging. SOURCE: Günter Bernhardt (bernhardt.guenter@mh-hannover.de) - Hannover Medical School
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