PLX306090

GSE150394: A1-Reactive Astrocytes and a loss of TREM2 are associated to an early state of pathology in a mouse model of Cerebral Amyloid Angiopathy

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In this study, we dissect in detail the glial and immune responses associated to early stages of CAA. To do so, RNAseq gene expression analysis were performed in a mouse model for Familial Danish Dementia (FDD), a neurodegenerative disease characterized by the accumulation of Danish amyloid (ADan) in the vasculature. Findings observed in this CAA mouse model were complemented with primary culture assays. SOURCE: Cristian Lasagna-Reeves Indiana University School of Medicine

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