PLX198054

GSE151190: Disruption of WNT-LMX1A Regulatory Loop During Midbrain Dopaminergic Neuron Development in Human DNAJC6 Parkinson Disease Model

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In this study, human isogenic model of juvenile onset PD caused by DNAJC6 mutation were made. Human ESCs edited using CRISPR-Cas9 to make deleterious DNAJC6 mutation was induced to human midbrain like organoid (hMLO) for studying the mechanism of DNAJC6 deleterious mutation in causing PD SOURCE: Wahyu,Handoko Wibowo,Darsono (wahyu_handoko@outlook.com) - Lee Sang-Hun Lab Hanyang University

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