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Learn MoreWe report the application of next-generation RNA and ATAC sequencing technology for high-throughput profiling of MLL-ENL transformed cell lines. According to our results, the C/EBP transcription factors coordinate the expression of the MLL-ENL/Hoxa target genes. Genetic removal of both Cebpa and Cebpb revealed a surrogate function of C/EBP for myeloid MLL-ENL transformation. SOURCE: Achim Leutz (aleutz@mdc-berlin.de) - Cell Differentiation and Tumorigenesis MDC Berlin
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