PLX185377

GSE37646: Distinct STAT5 concentrations uniquely control establishment and differentiation of mammary epithelium during pregnancy

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

To dissect regulatory processes of cell proliferation and differentiation we generated mouse strains carrying any combination of the four Stat5 alleles, thus expressing STAT5 from 0 to 100%. RNA-Seq analyses revealed that different STAT5 levels activate specific genetic programs linked to cell proliferation and differentiation. SOURCE: Keunsoo Kang (kangk2@niddk.nih.gov) - LGP NIH

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