PLX021576

GSE39812: Tryptamine Serves As a Proligand of the AhR Transcriptional Pathway, and the Activation Is Dependent of Monoamine Oxidases

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

In this study we show that physiological concentrations of tryptamine (TA) lead to induction of cytochrome P4501A1 transcription through an AhR-dependent mechanism. In addition, we show that activation of the AhR by TA requires a functional monoamino oxidase system, suggesting that TA acts as an AhR proligand possibly by converting to a high-affinity AhR ligand. SOURCE: Bernward Klocke (klocke@genomatix.de) - Genomatix Software GmbH

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