PLX213912

GSE62056: EZH2 inhibitor efficacy in non-Hodgkin lymphoma does not require suppression of H3K27 mono-methylation [RNA-Seq]

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Here we report the discovery of highly potent and selective EZH2 small molecule inhibitors, their validation by a cellular thermal shift assay, their application across a large lymphoma cell panel and their efficacy in GCBDLBCL xenograft models. SOURCE: Barbara,M,Bryant (barbara.bryant@constellationpharma.com) - Constellation Pharmaceuticals

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