PLX210983

GSE63755: Defective removal of ribonucleotides from DNA promotes systemic autoimmunity

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Constitutive low level DNA damage in RNASEH2 deficiency is linked to innate immune activation. Hierarchical clustering of over 16000 transcripts revealed remarkably similar profiles in patients with lupus erythematosus and patients with AGS with up-regulation of genes involved in DNA damage signaling and type I-IFN signaling. SOURCE: Min Ae Lee-Kirsch (MinAe.Lee-Kirsch@uniklinikum-dresden.de) - Molekulare Pädiatrie TU Dresden

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