PLX257746

GSE66160: RNA-seq on mouse E11.5 ventral midbrain neurosphere cultures treated with the LXR agonist GW3965 and the GSK3beta inhibitor CT99021

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We investigated mechanisms by which LXRs regulate midbrain dopaminergic neuron development. Using a systems biology approach, we found that LXR interacts with -catenin and that LXR activation inhibits the activity of the Wnt/-catenin pathway SOURCE: Sten LinnarssonMolecular Neurobiology Karolinska Institutet

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