PLX110427

GSE68083: TAF10 interacts with the GATA1 transcription factor and controls mouse erythropoiesis

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We have ablated TAF10 in the erythroid compartment only by crossing the TAF10lox mice with the EpoR-Cre mice and we have studied the development of the erythroid cells in vivo. TAF10 ablation led to embryonic death at E13.5 while at E12.5 there was a clear developmental defect which was reflected in the transcriptional profile of the fetal liver cells. Gata1-target genes were mostly affected and were responsible for the lethal phenotype. SOURCE: Petros Papadopoulos (petros.papadopoulos@med.kuleuven.be) - KU Leuven

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