PLX138622

GSE68921: Parkin-mediated mitophagy evokes perinatal cardiac mitochondria maturation

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Exclusion of Parkin from mitochondria of perinatal cardiomyocytes interrupts structural and molecular transformations essential to normal perinatal-adult mitochondrial replacement. mRNA-sequencing from cardiac total RNA was performed at P1, P21 and 5-week stages of nontransgenic (ntg) and human-Mfn2-overexpressing (Mfn2wt) hearts, and also of tet-off control (tetoff) and human-Mfn2 T111A/S442A-overexpressing (Mfn2AA) hearts. SOURCE: Scot,J,Matkovich (smatkovich@gmail.com) - Washington University School of Medicine

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