PLX052294

GSE74973: Expression of human C9ORF72 hexanucleotide expansion reproduces RNA foci and dipeptide repeat proteins but not neurodegeneration in BAC transgenic mice

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Nuclear RNA foci are often associated with mis-regulation of RNA processing in repeat expansion diseases. Here we report transcriptomic analysis of mice expressing expanded G4C2 repeats, the most common genetic cause of FTD/ALS. We show that the presence of numerous nuclear G4C2 repeat RNA foci does not cause extensive changes in RNA processing in this model organism. SOURCE: Helene Tran (helene.tran@umassmed.edu) - UMASS

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