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PLX239507
GSE76025: Pluripotent stem cell disease modeling of GATA6 haploinsufficiency in human pancreatic development
- Organsim human
- Type RNASEQ
- Target gene
- Project ARCHS4
To better understand molecular mechanisms of human pancreatic development associated with GATA6 haploinsufficiency, we performed RNA-seq analysis to characterize the biological processes affected by GATA6 heterozygous mutation.; We identified 542 differential expression genes in the mutants, of which 310 were downregulated. Gene ontology analysis showed that top downregulated transcription factors were associated with developmental process. SOURCE: Jeffrey Zhao (zhaoy@mskcc.org) - Memorial Sloan Kettering Cancer Center
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