Key Features
Enhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.
Learn MoreTo gain mechanistic insight into our finding that knockdown of miR-30 in HIECs and Caco-2 cells resulted in increased SOX9 mRNA, but decreased SOX9 protein expression, we performed RNA-sequencing on LNA30bcd-treated HIECs. We found 2440 significantly increased genes and 2651 significantly decreased genes across three time points (24 hours, 48 hours, and 72 hours post-transfection) relative to mock transfected cells. The up-regulated genes are highly enriched for both predicted miR-30 targets as well as genes in the ubiquitin-proteasome pathway. Inhibition of miR-30 also led to significantly reduced IEC proliferation and an increase in markers of enterocyte differentiation. SOURCE: Bailey Peck (bpeck@email.unc.edu) - Sethupathy University of North Carolina at Chapel Hill
View on GEOView in PlutoEnhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.
Learn MoreUse Pluto's intuitive interface to analyze and visualize data for this experiment. Pluto's platform is equipped with an API & SDKs, making it easy to integrate into your internal bioinformatics processes.
Read about post-pipeline analysisView quality control data and experiment metadata for this experiment.
Request imports from GEO or TCGA directly within Pluto Bio.
Chat with our Scientific Insights team