PLX122263

GSE83809: An essential cell cycle regulator drives chromatin condensation in maturing erythroblasts

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We report that Setd8 is essential for murine erythropoeisis. Setd8 null erythroblasts have severe defects in cell cycle progression, chromatin condensation,and heterochromatin integrity. They also have dysregulated gene expression. SOURCE: Laurie,A,Steiner (Laurie_Steiner@urmc.rochester.edu) - Steiner Lab University of Rochester

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