PLX252159

GSE85519: Expression profiling of cochlear ducts from P8 Gfi1cre/+ and Gfi1+/+ mice

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

The Gfi1-Cre mouse is commonly used for conditional hair cell-specific gene deletion/activation in the inner ear. However, we have shown that these mice produce a pattern of recombination that is not strictly limited to hair cells, and that Gfi1cre/+ mice exhibit an early onset progressive hearing loss as compared with their wildtype littermates. Here we performed a transcriptome analysis of Gfi1cre/+ and Gfi1+/+ cochlea to detect potential changes in gene expression that could contribute to their hearing loss phenotype, or that could potentially confound downstream analysis of conditional gene deletion using these mice. SOURCE: Ran Elkon Tel Aviv University