PLX085485

GSE87795: Single-cell transcriptome analysis of mouse fetal livers from different developmental stages

• Organsim mouse
• Type RNASEQ
• Target gene
• Project ARCHS4

We employed marker-free single-cell RNA-Seq to characterize comprehensive transcriptional profiles of 507 cells from seven stages between embryonic day 11.5 and postnatal day 2.5 during mouse liver development. Our data demonstrated the existence of two types of stem/progenitor cells with distinct molecular patterns during liver development. Both types of cells exhibit heterogeneity of transcriptional program within each cell population, suggesting they be in distinct status of self-renewal, cell proliferation and different sub-stages of differentiation and maturation. In general, our data depicting the dynamic trajectories with transcriptional profiles at single-cell resolution during mouse liver development provides insights into the fate decision and transcriptional control of self-renewal, differentiation and maturation of liver stem/progenitor cells. SOURCE: Xianbin Su (xbsu@sjtu.edu.cn) - Han Shanghai Jiao Tong University