Key Features
Enhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.
Learn MorePancreas development involves a coordinated process in which an early phase of cell segregation and patterning is proceeded by a longer phase of lineage restriction, expansion and extensive tissue remodeling. By combining quantitative clonal lineage tracing and whole-mount reconstruction with proliferation kinetics and single-cell transcriptional profiling, we define the functional basis of pancreas morphogenesis. Our results show that the large-scale organization of tissue can be traced to the activity of self-renewing precursors that localize at the termini of growing ductal branches and act collectively to drive serial rounds of stochastic ductal bifurcation balanced by termination. During this process, multipotent precursors give rise to self-renewing acinar-committed precursors, which are conveyed with growing ducts, as well as fate-restricted ductal progenitors that expand the trailing ducts and give rise to delaminating islet precursors. Together, these findings define quantitatively how the functional behavior and lineage progression of heterogeneous pools of the pancreatic precursors that define the organization of the organ. SOURCE: Evangelia Diamanti (ed347@cam.ac.uk) - Gottgens University of Cambridge
View on GEOView in PlutoEnhance your research with our curated data sets and powerful platform features. Pluto Bio makes it simple to find and use the data you need.
Learn MoreUse Pluto's intuitive interface to analyze and visualize data for this experiment. Pluto's platform is equipped with an API & SDKs, making it easy to integrate into your internal bioinformatics processes.
Read about post-pipeline analysisView quality control data and experiment metadata for this experiment.
Request imports from GEO or TCGA directly within Pluto Bio.
Chat with our Scientific Insights team