PLX136151

GSE91390: Distinct Brca1 mutations differentially reduce hematopoietic stem cell function

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

Mgbemena et al report that hematopoietic stem cells have an absolute requirement for Brca1 to survive. They also show that humanization of the mouse Brca1 e with a knocked-in BRCA1 cDNA, but not a mutant BRCA1/5382insC cDNA, fully substitutes for the mouse Brca1 during both embryonic development and hematopoiesis. SOURCE: Theo Ross (theo.ross@utsouthwestern.edu) - ND3.202 UT Southwestern Medical Center

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