PLX307985

GSE92725: AMPK signaling for nave pluripotency [Hs]

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We show activation of AMP kinase (AMPK) with single chemical compounds can endow nave pluripotency. AMPK activators reverted early-stage differentiating cells or epi-stem cells to nave state. Moreover, AMPK activators reverted human ESCs to nave state with pluripotent gene expression profiles and X-chromosome reactivation. SOURCE: Akira Watanabe (a.watanabe@cira.kyoto-u.ac.jp) - Department of Life Science Frontiers Kyoto University

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