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Learn MoreUsing RNA sequencing technology, we compared specic changes in the transcriptomic proles in human foreskin fibroblast cells (HFF-1) following ORFV infection. ORFV specically upregulated and downregulated a variety of genes, including genes involved in antiviral immune response, apoptosis, cell cycle and a series of signaling pathways, such as the IFN and p53-signaling pathways. A range of genes were downregulated at early stage. In contrast, the virus up-regulates a number of cellular genes at late stage. SOURCE: Daxiang Chen Southern Medical University
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