PLX033407

GSE95743: ICF-specific DNMT3B dysfunction interferes with intragenic regulation of mRNA transcription and alternative splicing (RNA-seq)

  • Organsim human
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We performed a transcriptomic and epigenomic study in patient-derived B-cell lines to investigate the genome-scale effects of DNMT3B dysfunction. We highlighted that altered intragenic CpG-methylation impairs multiple aspects of transcriptional regulation, like alternative TSS usage, antisense transcription and exon splicing. SOURCE: Miriam Gagliardi (miriam.gagliardi@igb.cnr.it) - IGB-CNR

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