PLX315716

GSE96061: The Quantitative Analysis of Transcriptomes Derived From Ezh2- or Ezh1/2-Deleted Leukemia Stem Cells of Murine Acute Myloid Leukemia

  • Organsim mouse
  • Type RNASEQ
  • Target gene
  • Project ARCHS4

We report dual genetic delstion of Ezh1/2 in murine AML model induced cell cyle progression of quiescent LSCs and cell differentiation of LSCs. To investigate the underlying mechanism by which Ezh1/2 regulate quiescent LSCs and maintein the stemness of LSCs, we performed RNA sequencing of L-GMPs derived from Ezh2- and Ezh1/2-deleted AML mice. SOURCE: Shuhei Fujita (shfujita@ncc.go.jp) - National Cancer Center

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